BDBM16391 5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl}-4-(2,4-difluorophenyl)-1,3-oxazole::triazolopyridine oxazole inhibitor 62

SMILES: Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1

InChI Key: InChIKey=VZTJNVJKEKIGHC-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16391   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM16391 (5-{3-cyclobutyl-[1,2,4]triazolo[3,4-a]pyridin-6-yl...) Show SMILES Fc1ccc(-c2ncoc2-c2ccc3nnc(C4CCC4)n3c2)c(F)c1 Show InChI InChI=1S/C19H14F2N4O/c20-13-5-6-14(15(21)8-13)17-18(26-10-22-17)12-4-7-16-23-24-19(25(16)9-12)11-2-1-3-11/h4-11H,1-3H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.75	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...				Bioorg Med Chem Lett 16: 4339-44 (2006) Article DOI: 10.1016/j.bmcl.2006.05.056 BindingDB Entry DOI: 10.7270/Q2251GFZ
					More data for this Ligand-Target Pair