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SMILES: Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl

InChI Key: InChIKey=DFXKTBBYAXAFEM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 164297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent N-type calcium channel subunit alpha-1B (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1G (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent L-type calcium channel subunit alpha-1C (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.4	n/a
SRMLSC US Patent					Assay Description To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair
Voltage-dependent T-type calcium channel subunit alpha-1H (Homo sapiens (Human))	BDBM164297 (US9688615, 108) Show SMILES Clc1cc2nc(CN3CCNCC3=O)[nH]c2cc1Cl Show InChI InChI=1S/C12H12Cl2N4O/c13-7-3-9-10(4-8(7)14)17-11(16-9)6-18-2-1-15-5-12(18)19/h3-4,15H,1-2,5-6H2,(H,16,17)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SRMLSC US Patent					Assay Description Cells were plated in 384-well, clear-bottom, black-walled, poly-D-lysine coated plates (Becton Dickinson, Franklin Lake, N.J.) 2 days prior to use in...				US Patent US9688615 (2017) BindingDB Entry DOI: 10.7270/Q27S7KXH
					More data for this Ligand-Target Pair