null

SMILES: CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12

InChI Key: InChIKey=LTGPGOCXUDPCMI-JXMROGBWSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 164839   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM164839 (US10604504, Example 16 | US11623921, Example 16 | ...) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12 Show InChI InChI=1S/C24H28N4O2/c1-14-16(3)26-23-19(24(25)30)12-11-18(22(14)23)17-8-6-9-20(15(17)2)27-21(29)10-7-13-28(4)5/h6-12,26H,13H2,1-5H3,(H2,25,30)(H,27,29)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				US Patent US9688629 (2017) BindingDB Entry DOI: 10.7270/Q20863G5
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM164839 (US10604504, Example 16 | US11623921, Example 16 | ...) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12 Show InChI InChI=1S/C24H28N4O2/c1-14-16(3)26-23-19(24(25)30)12-11-18(22(14)23)17-8-6-9-20(15(17)2)27-21(29)10-7-13-28(4)5/h6-12,26H,13H2,1-5H3,(H2,25,30)(H,27,29)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				US Patent US9802915 (2017) BindingDB Entry DOI: 10.7270/Q2JW8H17
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM164839 (US10604504, Example 16 | US11623921, Example 16 | ...) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12 Show InChI InChI=1S/C24H28N4O2/c1-14-16(3)26-23-19(24(25)30)12-11-18(22(14)23)17-8-6-9-20(15(17)2)27-21(29)10-7-13-28(4)5/h6-12,26H,13H2,1-5H3,(H2,25,30)(H,27,29)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2X06C0T
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM164839 (US10604504, Example 16 | US11623921, Example 16 | ...) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12 Show InChI InChI=1S/C24H28N4O2/c1-14-16(3)26-23-19(24(25)30)12-11-18(22(14)23)17-8-6-9-20(15(17)2)27-21(29)10-7-13-28(4)5/h6-12,26H,13H2,1-5H3,(H2,25,30)(H,27,29)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				US Patent US10604504 (2020) BindingDB Entry DOI: 10.7270/Q2H70JT2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM164839 (US10604504, Example 16 | US11623921, Example 16 | ...) Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1C)-c1ccc(C(N)=O)c2[nH]c(C)c(C)c12 Show InChI InChI=1S/C24H28N4O2/c1-14-16(3)26-23-19(24(25)30)12-11-18(22(14)23)17-8-6-9-20(15(17)2)27-21(29)10-7-13-28(4)5/h6-12,26H,13H2,1-5H3,(H2,25,30)(H,27,29)/b10-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.980	n/a	n/a	n/a	n/a	n/a	n/a
Montana State University					Assay Description To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...				J Med Chem 50: 4928-38 (2007) BindingDB Entry DOI: 10.7270/Q2474D50
					More data for this Ligand-Target Pair