BDBM165008 US9067917, 41::US9067917, 43::US9682971, 42

SMILES: OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F

InChI Key: InChIKey=HHTSKRULZHVWQT-RPBOFIJWSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 165008   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM165008 (US9067917, 41 | US9067917, 43 | US9682971, 42) Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F |r| Show InChI InChI=1S/C32H27F4N3O4/c33-26-15-23(43-32(34,35)36)12-10-20(26)17-39-29-14-13-22(42-18-21-11-9-19-5-1-4-8-27(19)37-21)16-28(29)38-30(39)24-6-2-3-7-25(24)31(40)41/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,40,41)/t24-,25+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9067917 (2015) BindingDB Entry DOI: 10.7270/Q24748M5
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM165008 (US9067917, 41 | US9067917, 43 | US9682971, 42) Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F |r| Show InChI InChI=1S/C32H27F4N3O4/c33-26-15-23(43-32(34,35)36)12-10-20(26)17-39-29-14-13-22(42-18-21-11-9-19-5-1-4-8-27(19)37-21)16-28(29)38-30(39)24-6-2-3-7-25(24)31(40)41/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,40,41)/t24-,25+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9067917 (2015) BindingDB Entry DOI: 10.7270/Q24748M5
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM165008 (US9067917, 41 | US9067917, 43 | US9682971, 42) Show SMILES OC(=O)[C@H]1CCCC[C@H]1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F |r| Show InChI InChI=1S/C32H27F4N3O4/c33-26-15-23(43-32(34,35)36)12-10-20(26)17-39-29-14-13-22(42-18-21-11-9-19-5-1-4-8-27(19)37-21)16-28(29)38-30(39)24-6-2-3-7-25(24)31(40)41/h1,4-5,8-16,24-25H,2-3,6-7,17-18H2,(H,40,41)/t24-,25+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9682971 (2017) BindingDB Entry DOI: 10.7270/Q2P26W84
					More data for this Ligand-Target Pair