BDBM16607 6-{[3-(trifluoromethyl)benzene]sulfonyl}-2,3-dihydropyridazin-3-one::Phenyl-Substituted Sulfonylpyridazinone, 8u

SMILES: FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(=O)[nH]n1

InChI Key: InChIKey=LGSWVTSRHBLFNZ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16607   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM16607 (6-{[3-(trifluoromethyl)benzene]sulfonyl}-2,3-dihyd...) Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(=O)[nH]n1 Show InChI InChI=1S/C11H7F3N2O3S/c12-11(13,14)7-2-1-3-8(6-7)20(18,19)10-5-4-9(17)15-16-10/h1-6H,(H,15,17)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	175	n/a	n/a	n/a	n/a	7.0	24
Pfizer					Assay Description The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...				J Med Chem 48: 6326-39 (2005) Article DOI: 10.1021/jm050462t BindingDB Entry DOI: 10.7270/Q2RN363Z
					More data for this Ligand-Target Pair