BDBM166097 US9067937, 41

SMILES: CC(=O)c1cnc2ccc(nc2c1Nc1cnc(nc1)N1CCC(N)C1)-c1cc(Cl)c(O)c(Cl)c1

InChI Key: InChIKey=VWUVJSLUODCSBG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 166097   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM166097 (US9067937, 41) Show SMILES CC(=O)c1cnc2ccc(nc2c1Nc1cnc(nc1)N1CCC(N)C1)-c1cc(Cl)c(O)c(Cl)c1 Show InChI InChI=1S/C24H21Cl2N7O2/c1-12(34)16-10-28-20-3-2-19(13-6-17(25)23(35)18(26)7-13)32-22(20)21(16)31-15-8-29-24(30-9-15)33-5-4-14(27)11-33/h2-3,6-10,14,35H,4-5,11,27H2,1H3,(H,28,31)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	25
OncoTherapy Science, Inc. US Patent					Assay Description MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...				US Patent US9067937 (2015) BindingDB Entry DOI: 10.7270/Q2BR8QX4
					More data for this Ligand-Target Pair