BDBM16622 6-({[2-fluoro-3-(trifluoromethyl)phenyl]methane}sulfonyl)-2,3-dihydropyridazin-3-one::Benzyl-Substituted Sulfonylpyridazinone, 15k

SMILES: Fc1c(CS(=O)(=O)c2ccc(=O)[nH]n2)cccc1C(F)(F)F

InChI Key: InChIKey=RGDMVBBLCMCNIE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM16622 (6-({[2-fluoro-3-(trifluoromethyl)phenyl]methane}su...) Show SMILES Fc1c(CS(=O)(=O)c2ccc(=O)[nH]n2)cccc1C(F)(F)F Show InChI InChI=1S/C12H8F4N2O3S/c13-11-7(2-1-3-8(11)12(14,15)16)6-22(20,21)10-5-4-9(19)17-18-10/h1-5H,6H2,(H,17,19)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...				J Med Chem 48: 6326-39 (2005) Article DOI: 10.1021/jm050462t BindingDB Entry DOI: 10.7270/Q2RN363Z
					More data for this Ligand-Target Pair