BDBM166918 US9073876, 4::US9732093, Compound 4

SMILES: Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2cccc(c2)C(O)=O)c1F

InChI Key: InChIKey=ZMVVONLLQMVZMG-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 166918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM166918 (US9073876, 4 | US9732093, Compound 4) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2cccc(c2)C(O)=O)c1F Show InChI InChI=1S/C22H20FN3O3/c23-20-17(18-10-26-19(24)11-25-18)8-7-16(14-4-2-5-14)21(20)29-12-13-3-1-6-15(9-13)22(27)28/h1,3,6-11,14H,2,4-5,12H2,(H2,24,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM166918 (US9073876, 4 | US9732093, Compound 4) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2cccc(c2)C(O)=O)c1F Show InChI InChI=1S/C22H20FN3O3/c23-20-17(18-10-26-19(24)11-25-18)8-7-16(14-4-2-5-14)21(20)29-12-13-3-1-6-15(9-13)22(27)28/h1,3,6-11,14H,2,4-5,12H2,(H2,24,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM166918 (US9073876, 4 | US9732093, Compound 4) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(OCc2cccc(c2)C(O)=O)c1F Show InChI InChI=1S/C22H20FN3O3/c23-20-17(18-10-26-19(24)11-25-18)8-7-16(14-4-2-5-14)21(20)29-12-13-3-1-6-15(9-13)22(27)28/h1,3,6-11,14H,2,4-5,12H2,(H2,24,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair