BDBM167111 US9073876, 195::US9732093, Compound 195

SMILES: OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1

InChI Key: InChIKey=IVLDVNQCNNDCFZ-UHFFFAOYSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 167111   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM167111 (US9073876, 195 | US9732093, Compound 195) Show SMILES OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1 Show InChI InChI=1S/C26H25FN2O4/c27-24-20(19-13-22-26(29-14-19)28-10-11-32-22)8-9-21(18-2-1-3-18)25(24)33-15-17-6-4-16(5-7-17)12-23(30)31/h4-9,13-14,18H,1-3,10-12,15H2,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9073876 (2015) BindingDB Entry DOI: 10.7270/Q28S4NPC
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167111 (US9073876, 195 | US9732093, Compound 195) Show SMILES OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1 Show InChI InChI=1S/C26H25FN2O4/c27-24-20(19-13-22-26(29-14-19)28-10-11-32-22)8-9-21(18-2-1-3-18)25(24)33-15-17-6-4-16(5-7-17)12-23(30)31/h4-9,13-14,18H,1-3,10-12,15H2,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167111 (US9073876, 195 | US9732093, Compound 195) Show SMILES OC(=O)Cc1ccc(COc2c(F)c(ccc2C2CCC2)-c2cnc3NCCOc3c2)cc1 Show InChI InChI=1S/C26H25FN2O4/c27-24-20(19-13-22-26(29-14-19)28-10-11-32-22)8-9-21(18-2-1-3-18)25(24)33-15-17-6-4-16(5-7-17)12-23(30)31/h4-9,13-14,18H,1-3,10-12,15H2,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair