BDBM168221 US9669031, 50 N-[6-[(8-chloro-4′,4′-difluoro-1,5-dioxo-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-6-yl)amino]pyrimidin-4-yl]cyclopropanecarboxamide (Cpd. No. 50)::US9669031, 99 6-[(6-aminopyrimidin-4-yl)amino]-8-chloro-4′,4′-difluoro-spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 99)

SMILES: FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21

InChI Key: InChIKey=WUCBMAZIUGCYRG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 168221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168221 (US9669031, 50 N-[6-[(8-chloro-4′,4′-di...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168221 (US9669031, 50 N-[6-[(8-chloro-4′,4′-di...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM168221 (US9669031, 50 N-[6-[(8-chloro-4′,4′-di...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM168221 (US9669031, 50 N-[6-[(8-chloro-4′,4′-di...) Show SMILES FC1(F)CCC2(CC1)NC(=O)c1c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n21 Show InChI InChI=1S/C20H19ClF2N6O3/c21-11-7-12(26-13-8-14(25-9-24-13)27-16(30)10-1-2-10)18(32)29-15(11)17(31)28-20(29)5-3-19(22,23)4-6-20/h7-10H,1-6H2,(H,28,31)(H2,24,25,26,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	25
eFFECTOR THERAPEUTICS, INC. US Patent					Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re...				US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT
					More data for this Ligand-Target Pair