BDBM168281 US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spiro[2H-imidazo[1,5-a]pyridine-3,1′-cyclohexane]-1,5-dione hydrochloride (Cpd. No. 109)
SMILES: Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
InChI Key: InChIKey=OEVBYHNIUPOXDX-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at km concentration by ADP-Glo... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E-derived peptide as substrate in presence of ATP at Km concentration by ADP-Glo... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of 10XKm in presence... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of Km/10 in presence... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at concentration of 10XKm in presence... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at Km concentratio... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at Km concentratio... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at Km concentration in presence of AT... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant His-tagged MNK2 (unknown origin) using eIF4E derived peptide as substrate at concentration of Km/10 in presence... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Australia Curated by ChEMBL | Assay Description Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at Km concentration in presence of AT... | Bioorg Med Chem Lett 29: 2650-2654 (2019) Article DOI: 10.1016/j.bmcl.2019.07.043 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | 25 |
eFFECTOR THERAPEUTICS, INC. US Patent | Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re... | US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM168281 (US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | 25 |
eFFECTOR THERAPEUTICS, INC. US Patent | Assay Description Compounds are screened for Mnk inhibition using the ADP-Glo kinase assay kit (Promega, catalogue No. V9101). All kinase reactions are performed in Re... | US Patent US9669031 (2017) BindingDB Entry DOI: 10.7270/Q26Q1VDT | |||||||||||
More data for this Ligand-Target Pair |