null

SMILES: CN1CCc2nc(NC(=O)c3cccc(c3)[C@H]3CCCN3C(=O)c3cn4cc(ccc4n3)C(N)=O)sc2C1

InChI Key: InChIKey=ISODQVKLZILGBD-OAQYLSRUSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 169541   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM169541 (US9079880, 74) Show SMILES CN1CCc2nc(NC(=O)c3cccc(c3)[C@H]3CCCN3C(=O)c3cn4cc(ccc4n3)C(N)=O)sc2C1 |r| Show InChI InChI=1S/C27H27N7O3S/c1-32-11-9-19-22(15-32)38-27(30-19)31-25(36)17-5-2-4-16(12-17)21-6-3-10-34(21)26(37)20-14-33-13-18(24(28)35)7-8-23(33)29-20/h2,4-5,7-8,12-14,21H,3,6,9-11,15H2,1H3,(H2,28,35)(H,30,31,36)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.40	n/a	n/a	n/a	n/a	7.2	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...				US Patent US9079880 (2015) BindingDB Entry DOI: 10.7270/Q25X27QJ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM169541 (US9079880, 74) Show SMILES CN1CCc2nc(NC(=O)c3cccc(c3)[C@H]3CCCN3C(=O)c3cn4cc(ccc4n3)C(N)=O)sc2C1 |r| Show InChI InChI=1S/C27H27N7O3S/c1-32-11-9-19-22(15-32)38-27(30-19)31-25(36)17-5-2-4-16(12-17)21-6-3-10-34(21)26(37)20-14-33-13-18(24(28)35)7-8-23(33)29-20/h2,4-5,7-8,12-14,21H,3,6,9-11,15H2,1H3,(H2,28,35)(H,30,31,36)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The activity of ROCKII (1-543) kinase was measured utilizing Cambrex PKLight ATP Detection Reagent, a homogeneous assay technology using luciferin-lu...				US Patent US9079880 (2015) BindingDB Entry DOI: 10.7270/Q25X27QJ
					More data for this Ligand-Target Pair