null

SMILES: Nc1nonc1-n1nnc(C(=O)N2CCC[C@@H]2c2cccc(c2)C(=O)Nc2nc3CC[C@@H](Cc3s2)N2CCOCC2)c1-c1ccccc1

InChI Key: InChIKey=CZIZIHYOQJSLMR-UKILVPOCSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 169601   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM169601 (US9079880, 134) Show SMILES Nc1nonc1-n1nnc(C(=O)N2CCC[C@@H]2c2cccc(c2)C(=O)Nc2nc3CC[C@@H](Cc3s2)N2CCOCC2)c1-c1ccccc1 |r| Show InChI InChI=1S/C33H34N10O4S/c34-29-30(39-47-38-29)43-28(20-6-2-1-3-7-20)27(37-40-43)32(45)42-13-5-10-25(42)21-8-4-9-22(18-21)31(44)36-33-35-24-12-11-23(19-26(24)48-33)41-14-16-46-17-15-41/h1-4,6-9,18,23,25H,5,10-17,19H2,(H2,34,38)(H,35,36,44)/t23-,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.2	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description This assay is performed using FAM S6 substrate peptide (Catalogue #R7184) and IMAP FP Screening Express Kit detection reagents from Molecular Devices...				US Patent US9079880 (2015) BindingDB Entry DOI: 10.7270/Q25X27QJ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM169601 (US9079880, 134) Show SMILES Nc1nonc1-n1nnc(C(=O)N2CCC[C@@H]2c2cccc(c2)C(=O)Nc2nc3CC[C@@H](Cc3s2)N2CCOCC2)c1-c1ccccc1 |r| Show InChI InChI=1S/C33H34N10O4S/c34-29-30(39-47-38-29)43-28(20-6-2-1-3-7-20)27(37-40-43)32(45)42-13-5-10-25(42)21-8-4-9-22(18-21)31(44)36-33-35-24-12-11-23(19-26(24)48-33)41-14-16-46-17-15-41/h1-4,6-9,18,23,25H,5,10-17,19H2,(H2,34,38)(H,35,36,44)/t23-,25+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.70	n/a	n/a	n/a	n/a	7.5	n/a
Boehringer Ingelheim International GmbH US Patent					Assay Description The activity of ROCKII (1-543) kinase was measured utilizing Cambrex PKLight ATP Detection Reagent, a homogeneous assay technology using luciferin-lu...				US Patent US9079880 (2015) BindingDB Entry DOI: 10.7270/Q25X27QJ
					More data for this Ligand-Target Pair