BDBM17033 (3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indole-5-carboxamide::Indolinone based inhibitor, 3e
SMILES: NC(=O)c1ccc2NC(=O)\C(=C/c3ccc[nH]3)c2c1
InChI Key: InChIKey=NHBOFPSPSSKHHA-XFFZJAGNSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human)) | BDBM17033![]() ((3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.2 | 22 |
Berlex Biosciences | Assay Description The coupled assay can detect inhibitors of AKT2 activation, as well as direct inhibitors of PDK1 or AKT2. Inactive AKT2 is activated in situ by incub... | Bioorg Med Chem Lett 17: 3814-8 (2007) Article DOI: 10.1016/j.bmcl.2007.04.071 BindingDB Entry DOI: 10.7270/Q25Q4TBB | |||||||||||
More data for this Ligand-Target Pair |