BDBM170776 US9085555, 204

SMILES: CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)NCc1cccc(Cl)c1F)C(=O)Nc1cn(C(N)=O)c2ccccc12

InChI Key: InChIKey=NAXCBXBOWJPZLE-RYGJVYDSSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 170776   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor D (Homo sapiens (Human))	BDBM170776 (US9085555, 204) Show SMILES CO[C@@H]1[C@@H](F)CN([C@@H]1C(=O)NCc1cccc(Cl)c1F)C(=O)Nc1cn(C(N)=O)c2ccccc12 |r| Show InChI InChI=1S/C23H22ClF2N5O4/c1-35-20-15(25)10-31(19(20)21(32)28-9-12-5-4-7-14(24)18(12)26)23(34)29-16-11-30(22(27)33)17-8-3-2-6-13(16)17/h2-8,11,15,19-20H,9-10H2,1H3,(H2,27,33)(H,28,32)(H,29,34)/t15-,19-,20+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	7.5	25
NOVARTIS AG US Patent					Assay Description Recombinant human factor D (expressed in E. coli and purified using standard methods) at 10 nM concentration is incubated with test compound at vario...				US Patent US9085555 (2015) BindingDB Entry DOI: 10.7270/Q2RN36MP
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