BDBM172089 US10155002, Compound 95::US9090562, 95
SMILES: CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CNC[C@@H](O)CO)cc1
InChI Key:
Data: 4 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.55 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 1.55 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
EZH2(Y641F) (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.55 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172089 (US10155002, Compound 95 | US11052093, Compound 95 ...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.77 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair |