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SMILES: Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cnccn3)nn12

InChI Key: InChIKey=HWTJHLCFUZPPNL-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 173193   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM173193
PNG
(US9096589, 5,8-Dimethyl-2-[2-(1-methyl-4-pyrazin-2...)
Show SMILES Cc1cnc(C)c2nc(CCc3nc(cn3C)-c3cnccn3)nn12
Show InChI InChI=1S/C17H18N8/c1-11-8-20-12(2)17-22-15(23-25(11)17)4-5-16-21-14(10-24(16)3)13-9-18-6-7-19-13/h6-10H,4-5H2,1-3H3
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Similars
US Patent
n/an/a 0.520n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...

US Patent US9096589 (2015)


BindingDB Entry DOI: 10.7270/Q25Q4TTM
More data for this
Ligand-Target Pair