BDBM173298 US10323032, Example 35::US9096596, 35::US9604982, Example 35

SMILES: Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F

InChI Key: InChIKey=GFRAMLAUMXWEGU-UHFFFAOYSA-N

Data: 8 KI  8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 173298   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Milano					Assay Description Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...				Bioorg Med Chem 17: 5834-56 (2009) BindingDB Entry DOI: 10.7270/Q21Z46SW
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	12.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9096596 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1JC6
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	39.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9096596 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1JC6
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	39.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Milano					Assay Description Human or rat P2X7-1321 N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according...				Bioorg Med Chem 17: 5834-56 (2009) BindingDB Entry DOI: 10.7270/Q21Z46SW
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	39.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	39.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Milano					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				Bioorg Med Chem 17: 5834-56 (2009) BindingDB Entry DOI: 10.7270/Q21Z46SW
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Milano					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				Bioorg Med Chem 17: 5834-56 (2009) BindingDB Entry DOI: 10.7270/Q21Z46SW
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	269	n/a	n/a	n/a	n/a	7.4	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...				US Patent US9096596 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1JC6
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (Homo sapiens (Human))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.3	n/a	n/a	n/a	n/a	7.4	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high gluc...				US Patent US9096596 (2015) BindingDB Entry DOI: 10.7270/Q2SJ1JC6
					More data for this Ligand-Target Pair
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat))	BDBM173298 (US10323032, Example 35 | US9096596, 35 | US9604982...) Show SMILES Cc1nc2CN(CCc2c(n1)-c1[nH]ncc1F)C(=O)c1cccc(c1Cl)C(F)(F)F Show InChI InChI=1S/C19H14ClF4N5O/c1-9-26-14-8-29(6-5-10(14)16(27-9)17-13(21)7-25-28-17)18(30)11-3-2-4-12(15(11)20)19(22,23)24/h2-4,7H,5-6,8H2,1H3,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	269	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according...				US Patent US9604982 (2017) BindingDB Entry DOI: 10.7270/Q2B56MTX
					More data for this Ligand-Target Pair