BDBM174802 US10053462, 33::US9102686, 33::US9540388, 32
SMILES: FC(F)(F)c1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nnc(-c4ccccn4)n2C3)c1Cl
InChI Key: InChIKey=GJFWSWDCNPBEIO-BLLLJJGKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.20 | n/a | 11 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.20 | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.20 | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Mus musculus) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 6.30 | n/a | 1.51E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 6.30 | n/a | 2.11E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Human or rat P2X7-1321N1 cells were collected and frozen @-80.degree. C. On the day of the experiment, cell membrane preparations were made according... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @ −80° C. On the day of the experiment, cell membrane preparations were made according... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 11 | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description human or rat P2X7-1321N1 cells were collected and frozen @−80° C. On the day of the experiment, cell membrane preparations were made according ... | US Patent US9540388 (2017) BindingDB Entry DOI: 10.7270/Q20V8B0D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Mus musculus) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (P2X7) (Rattus norvegicus (Rat)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11.3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description Ca.sup.2+flux: 1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Me... | US Patent US9102686 (2015) BindingDB Entry DOI: 10.7270/Q22V2DXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
P2X purinoceptor 7 (Homo sapiens (Human)) | BDBM174802 (US10053462, 33 | US9102686, 33 | US9540388, 32) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 13.4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Janssen Pharmaceutica NV US Patent | Assay Description 1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose... | US Patent US10053462 (2018) BindingDB Entry DOI: 10.7270/Q2KK9DSF | |||||||||||
More data for this Ligand-Target Pair |