BDBM175065 US9688678, 26 (+-)-3-(2-methoxyphenyl)-1-[(5-methoxy-2-pyridyl)sulfonyl]-3-[2-(4-methylpiperazin-1-yl)-6-azaspiro[3.3]heptan-6-yl]-2-oxo-indoline-5-carbonitrile

SMILES: COc1ccc(nc1)S(=O)(=O)N1C2C=CC(=CC2C(N2CC3(CN(C3)N3CCN(C)CC3)C2)(C1=O)c1ccccc1OC)C#N

InChI Key: InChIKey=PFYJSXOIEFLDNQ-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 175065   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vasopressin V1b receptor (V1b) (Homo sapiens (Human))	BDBM175065 (US9688678, 26 (+-)-3-(2-methoxyphenyl)-1-[(5-metho...) Show SMILES COc1ccc(nc1)S(=O)(=O)N1C2C=CC(=CC2C(N2CC3(CN(C3)N3CCN(C)CC3)C2)(C1=O)c1ccccc1OC)C#N |c:14,16| Show InChI InChI=1S/C32H37N7O5S/c1-35-12-14-37(15-13-35)38-21-31(22-38)19-36(20-31)32(25-6-4-5-7-28(25)44-3)26-16-23(17-33)8-10-27(26)39(30(32)40)45(41,42)29-11-9-24(43-2)18-34-29/h4-11,16,18,26-27H,12-15,19-22H2,1-3H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	5.5	-11.3	n/a	n/a	n/a	n/a	n/a	7.4	25
AbbVie Deutschland GmbH & Co. KG US Patent					Assay Description The binding assay was carried out by the method based on that of Tahara et al. (Tahara A et al., Brit. J. Pharmacol. 125, 1463-1470 (1998)). The incu...				US Patent US9688678 (2017) BindingDB Entry DOI: 10.7270/Q2SN0740
					More data for this Ligand-Target Pair