BDBM175906 US9688684, Compound 103: 8-(4-Butoxy-phenyl)-7-(3-methyl-benzyl)-5,6,7,8-tetrahydro-tetrazolo[1,5-a]pyrazine
SMILES: CCCCOc1ccc(cc1)C1N(Cc2cccc(C)c2)CCn2nnnc12
InChI Key: InChIKey=JRMSNFUYRQVNAU-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Retinoid-related orphan receptor gamma (RORγ-LBD) (Homo sapiens (Human)) | BDBM175906 (US9688684, Compound 103: 8-(4-Butoxy-phenyl)-7-(3-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Patent GmbH US Patent | Assay Description For the assay 12,500 293T cells (DSMZ no ACC 635) per 384 well are seeded in 30 μl inMEM Eagle medium, supplemented with 10% FBS, 2 mM Glutamax,... | US Patent US9688684 (2017) BindingDB Entry DOI: 10.7270/Q2DB7ZZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Retinoid-related orphan receptor gamma (RORγ-LBD) (Homo sapiens (Human)) | BDBM175906 (US9688684, Compound 103: 8-(4-Butoxy-phenyl)-7-(3-...) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 6.8 | n/a |
Merck Patent GmbH US Patent | Assay Description In this assay, a GST-tagged human RORγ ligand binding domain (GST-hRORγ-LBD) interacts with a synthetic biotinylated TRAP220 cofactor pepti... | US Patent US9688684 (2017) BindingDB Entry DOI: 10.7270/Q2DB7ZZK | |||||||||||
More data for this Ligand-Target Pair |