BDBM176272 US10047103, 305::US9688695, 305

SMILES: COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1

InChI Key: InChIKey=KOQWYAURZBRJBF-UHFFFAOYSA-N

Data: 1 IC50  3 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176272   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM176272 (US10047103, 305 | US9688695, 305) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1 Show InChI InChI=1S/C27H20F3N5O5S2/c1-37-17-7-20(18-9-22(40-21(18)8-17)19-10-35-25(33-19)42-26(34-35)38-2)39-11-16-12-41-24(32-16)15-5-3-14(4-6-15)23(36)31-13-27(28,29)30/h3-10,12H,11,13H2,1-2H3,(H,31,36)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	25
BRISTOL-MYERS SQUIBB COMPANY US Patent					Assay Description Briefly, HEK293 EBNA PAR4 clone 20664.1J cells were plated 24 hrs. prior to experiment in 384 well, Poly-D-Lysine coated, black, clear bottom plates ...				US Patent US9688695 (2017) BindingDB Entry DOI: 10.7270/Q28K777N
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM176272 (US10047103, 305 | US9688695, 305) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1 Show InChI InChI=1S/C27H20F3N5O5S2/c1-37-17-7-20(18-9-22(40-21(18)8-17)19-10-35-25(33-19)42-26(34-35)38-2)39-11-16-12-41-24(32-16)15-5-3-14(4-6-15)23(36)31-13-27(28,29)30/h3-10,12H,11,13H2,1-2H3,(H,31,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The ability of the compounds of the current invention to inhibit platelet aggregation induced by gamma-thrombin was tested in a 96-well microplate ag...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM176272 (US10047103, 305 | US9688695, 305) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1 Show InChI InChI=1S/C27H20F3N5O5S2/c1-37-17-7-20(18-9-22(40-21(18)8-17)19-10-35-25(33-19)42-26(34-35)38-2)39-11-16-12-41-24(32-16)15-5-3-14(4-6-15)23(36)31-13-27(28,29)30/h3-10,12H,11,13H2,1-2H3,(H,31,36)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	25
Bristol-Myers Squibb Company; Universite de Montreal US Patent					Assay Description The activity of the PAR4 antagonists of the present invention were tested in PAR4 expressing cells by monitoring H-Ala-Phe(4-F)-Pro-Gly-Trp-Leu-Val-L...				US Patent US10047103 (2018) BindingDB Entry DOI: 10.7270/Q2QF8VWN
					More data for this Ligand-Target Pair
Proteinase-activated receptor 4 (PAR4) (Homo sapiens (Human))	BDBM176272 (US10047103, 305 | US9688695, 305) Show SMILES COc1nn2cc(nc2s1)-c1cc2c(OCc3csc(n3)-c3ccc(cc3)C(=O)NCC(F)(F)F)cc(OC)cc2o1 Show InChI InChI=1S/C27H20F3N5O5S2/c1-37-17-7-20(18-9-22(40-21(18)8-17)19-10-35-25(33-19)42-26(34-35)38-2)39-11-16-12-41-24(32-16)15-5-3-14(4-6-15)23(36)31-13-27(28,29)30/h3-10,12H,11,13H2,1-2H3,(H,31,36)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	25
BRISTOL-MYERS SQUIBB COMPANY US Patent					Assay Description Briefly, PRP or washed platelet suspension (100 μl) was pre-incubated for 5 minutes at room temperature with varying concentrations of compounds...				US Patent US9688695 (2017) BindingDB Entry DOI: 10.7270/Q28K777N
					More data for this Ligand-Target Pair