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SMILES: CS(=O)(=O)Nc1cccc(c1)C(=O)NCC(O)CN1CCc2ccccc2C1

InChI Key: InChIKey=RHXJNLFCFWJXPY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 176849   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176849 (US10307413, Compound 24 | US10391089, Compound 24 ...) Show SMILES CS(=O)(=O)Nc1cccc(c1)C(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C20H25N3O4S/c1-28(26,27)22-18-8-4-7-16(11-18)20(25)21-12-19(24)14-23-10-9-15-5-2-3-6-17(15)13-23/h2-8,11,19,22,24H,9-10,12-14H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US9675614 (2017) BindingDB Entry DOI: 10.7270/Q2MW2F9B
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176849 (US10307413, Compound 24 | US10391089, Compound 24 ...) Show SMILES CS(=O)(=O)Nc1cccc(c1)C(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C20H25N3O4S/c1-28(26,27)22-18-8-4-7-16(11-18)20(25)21-12-19(24)14-23-10-9-15-5-2-3-6-17(15)13-23/h2-8,11,19,22,24H,9-10,12-14H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10980794 (2021)
					More data for this Ligand-Target Pair
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176849 (US10307413, Compound 24 | US10391089, Compound 24 ...) Show SMILES CS(=O)(=O)Nc1cccc(c1)C(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C20H25N3O4S/c1-28(26,27)22-18-8-4-7-16(11-18)20(25)21-12-19(24)14-23-10-9-15-5-2-3-6-17(15)13-23/h2-8,11,19,22,24H,9-10,12-14H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme, Inc. US Patent					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				US Patent US10391089 (2019) BindingDB Entry DOI: 10.7270/Q2RN3B7D
					More data for this Ligand-Target Pair
Protein arginine N-methyltransferase 5 (Homo sapiens (Human))	BDBM176849 (US10307413, Compound 24 | US10391089, Compound 24 ...) Show SMILES CS(=O)(=O)Nc1cccc(c1)C(=O)NCC(O)CN1CCc2ccccc2C1 Show InChI InChI=1S/C20H25N3O4S/c1-28(26,27)22-18-8-4-7-16(11-18)20(25)21-12-19(24)14-23-10-9-15-5-2-3-6-17(15)13-23/h2-8,11,19,22,24H,9-10,12-14H2,1H3,(H,21,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The assays were all performed in a buffer consisting of 20 mM Bicine (pH=7.6), 1 mM TCEP, 0.005% BSG, and 0.002% Tween20, prepared on the day of use....				J Med Chem 52: 3073-83 (2009) BindingDB Entry DOI: 10.7270/Q2ZG6VMT
					More data for this Ligand-Target Pair