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SMILES: COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(Nc3ccc(cc3)C(N)=O)c2c1

InChI Key: InChIKey=IOSFHNPPCPJQLY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 177180   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Maternal embryonic leucine zipper kinase


(Homo sapiens (Human))		BDBM177180
PNG
(US9120749, 546)
Show SMILES COc1cc(cc(Cl)c1O)-c1ccc2ncc(C(=O)C3CC3)c(Nc3ccc(cc3)C(N)=O)c2c1
Show InChI InChI=1S/C27H22ClN3O4/c1-35-23-12-17(11-21(28)26(23)33)16-6-9-22-19(10-16)24(20(13-30-22)25(32)14-2-3-14)31-18-7-4-15(5-8-18)27(29)34/h4-14,33H,2-3H2,1H3,(H2,29,34)(H,30,31)
PDB

KEGG

UniProtKB/SwissProt

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UniChem

Similars
US Patent
n/an/a 40n/an/an/an/a7.425



ONCOTHERAPY SCIENCE, INC.

US Patent


Assay Description
MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...

US Patent US9120749 (2015)


BindingDB Entry DOI: 10.7270/Q2FX7872
More data for this
Ligand-Target Pair