BDBM177768 US9120785, Example 14-14

SMILES: Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C(C)(O)C1CCC(C1)C(O)=O

InChI Key: InChIKey=TXJZHEPRGKFTNQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 177768   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM177768 (US9120785, Example 14-14) Show SMILES Cc1cc(Nc2cc(ccn2)C(F)(F)F)nc(c1)-c1cnc(s1)C(C)(O)C1CCC(C1)C(O)=O Show InChI InChI=1S/C23H23F3N4O3S/c1-12-7-16(29-19(8-12)30-18-10-15(5-6-27-18)23(24,25)26)17-11-28-21(34-17)22(2,33)14-4-3-13(9-14)20(31)32/h5-8,10-11,13-14,33H,3-4,9H2,1-2H3,(H,31,32)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description Homogeneous Time-Resolved Fluorescence (HTRF) assay for the recombinant human Syk enzyme: A recombinant GST-hSyk fusion protein was used to measure p...				US Patent US9120785 (2015) BindingDB Entry DOI: 10.7270/Q2959G9C
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