BDBM177891 US9120791, Example 121::US9603854, 121

SMILES: Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccncc12)c1cccc(F)c1

InChI Key: InChIKey=HDDUGVRHHUZCJU-YTTGMZPUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177891   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177891 (US9120791, Example 121 | US9603854, 121) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccncc12)c1cccc(F)c1 Show InChI InChI=1S/C42H36FN5O6/c43-29-6-3-7-31(19-29)48(30-8-10-33(49)11-9-30)42(51)36-20-37(46-13-12-44-23-38(36)46)34-21-39-40(54-26-53-39)22-35(34)41(50)47-24-28-5-2-1-4-27(28)18-32(47)25-45-14-16-52-17-15-45/h1-13,19-23,32,49H,14-18,24-26H2/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177891 (US9120791, Example 121 | US9603854, 121) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2ccncc12)c1cccc(F)c1 Show InChI InChI=1S/C42H36FN5O6/c43-29-6-3-7-31(19-29)48(30-8-10-33(49)11-9-30)42(51)36-20-37(46-13-12-44-23-38(36)46)34-21-39-40(54-26-53-39)22-35(34)41(50)47-24-28-5-2-1-4-27(28)18-32(47)25-45-14-16-52-17-15-45/h1-13,19-23,32,49H,14-18,24-26H2/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	34	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair