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SMILES: CC1Cc2c([nH]c3ccc(Br)cc23)C2(CCC(CC2)(N(C)C)c2ccccc2)O1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 177918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mu-type opioid receptor (Homo sapiens (Human))	BDBM177918 (US9120797, 16) Show SMILES CC1Cc2c([nH]c3ccc(Br)cc23)C2(CCC(CC2)(N(C)C)c2ccccc2)O1 |(-3.24,-3.6,;-2.47,-2.26,;-3.24,-.93,;-2.47,.4,;-.93,.4,;-.45,1.87,;-1.7,2.77,;-1.86,4.3,;-3.27,4.93,;-4.51,4.03,;-6,4.42,;-4.35,2.49,;-2.95,1.87,;-.16,-.93,;.61,-2.26,;2.15,-2.26,;2.92,-.93,;2.15,.4,;.61,.4,;4.01,.16,;5.5,-.24,;3.61,1.65,;3.69,-2.26,;2.92,-3.6,;3.69,-4.93,;5.23,-4.93,;6,-3.6,;5.23,-2.26,;-.93,-2.26,)| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	14	-10.7	n/a	n/a	n/a	n/a	n/a	n/a	25
Gruenenthal GmbH US Patent					Assay Description The receptor affinity for the human mu-opiate receptor was determined in a homogeneous batch in microtitre plates. For this, dilution series of the p...				US Patent US9120797 (2015) BindingDB Entry DOI: 10.7270/Q2X065T3
					More data for this Ligand-Target Pair
Opioid growth factor receptor-like protein 1 (Homo sapiens (Human))	BDBM177918 (US9120797, 16) Show SMILES CC1Cc2c([nH]c3ccc(Br)cc23)C2(CCC(CC2)(N(C)C)c2ccccc2)O1 |(-3.24,-3.6,;-2.47,-2.26,;-3.24,-.93,;-2.47,.4,;-.93,.4,;-.45,1.87,;-1.7,2.77,;-1.86,4.3,;-3.27,4.93,;-4.51,4.03,;-6,4.42,;-4.35,2.49,;-2.95,1.87,;-.16,-.93,;.61,-2.26,;2.15,-2.26,;2.92,-.93,;2.15,.4,;.61,.4,;4.01,.16,;5.5,-.24,;3.61,1.65,;3.69,-2.26,;2.92,-3.6,;3.69,-4.93,;5.23,-4.93,;6,-3.6,;5.23,-2.26,;-.93,-2.26,)| Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	23	-10.4	n/a	n/a	n/a	n/a	n/a	7.4	25
Gruenenthal GmbH US Patent					Assay Description The cyclohexane derivatives of the general formula I were investigated in a receptor binding assay with 3H-nociceptin/orphanin FQ with membranes from...				US Patent US9120797 (2015) BindingDB Entry DOI: 10.7270/Q2X065T3
					More data for this Ligand-Target Pair