BDBM17811 benzimidazole-urea, 38::methyl N-{6-[4-({[2-fluoro-5-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1-methyl-1H-1,3-benzodiazol-2-yl}carbamate

SMILES: COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2n1C

InChI Key: InChIKey=PXXIFHQHWGNCHG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17811   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17811 (benzimidazole-urea, 38 | methyl N-{6-[4-({[2-fluor...) Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2n1C Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-12-16(8-10-18(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-19-11-13(24(26,27)28)3-9-17(19)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...				J Med Chem 50: 4453-70 (2007) Article DOI: 10.1021/jm0611051 BindingDB Entry DOI: 10.7270/Q20V8B29
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM17811 (benzimidazole-urea, 38 | methyl N-{6-[4-({[2-fluor...) Show SMILES COC(=O)Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2n1C Show InChI InChI=1S/C24H19F4N5O4/c1-33-20-12-16(8-10-18(20)30-21(33)32-23(35)36-2)37-15-6-4-14(5-7-15)29-22(34)31-19-11-13(24(26,27)28)3-9-17(19)25/h3-12H,1-2H3,(H2,29,31,34)(H,30,32,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...				J Med Chem 50: 4453-70 (2007) Article DOI: 10.1021/jm0611051 BindingDB Entry DOI: 10.7270/Q20V8B29
					More data for this Ligand-Target Pair