BDBM17818 1-{4-[(2-amino-1H-1,3-benzodiazol-6-yl)oxy]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea::benzimidazole-urea, 45

SMILES: Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1

InChI Key: InChIKey=GKOMRRDSXJXWIK-UHFFFAOYSA-N

Data: 2 IC50

PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 17818   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17818 (1-{4-[(2-amino-1H-1,3-benzodiazol-6-yl)oxy]phenyl}...) Show SMILES Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1 Show InChI InChI=1S/C21H15F4N5O2/c22-15-7-1-11(21(23,24)25)9-17(15)30-20(31)27-12-2-4-13(5-3-12)32-14-6-8-16-18(10-14)29-19(26)28-16/h1-10H,(H3,26,28,29)(H2,27,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...				J Med Chem 50: 4453-70 (2007) Article DOI: 10.1021/jm0611051 BindingDB Entry DOI: 10.7270/Q20V8B29
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM17818 (1-{4-[(2-amino-1H-1,3-benzodiazol-6-yl)oxy]phenyl}...) Show SMILES Nc1nc2ccc(Oc3ccc(NC(=O)Nc4cc(ccc4F)C(F)(F)F)cc3)cc2[nH]1 Show InChI InChI=1S/C21H15F4N5O2/c22-15-7-1-11(21(23,24)25)9-17(15)30-20(31)27-12-2-4-13(5-3-12)32-14-6-8-16-18(10-14)29-19(26)28-16/h1-10H,(H3,26,28,29)(H2,27,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assay uses purified GST-Tie-2 or GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium cryptate...				J Med Chem 50: 4453-70 (2007) Article DOI: 10.1021/jm0611051 BindingDB Entry DOI: 10.7270/Q20V8B29
					More data for this Ligand-Target Pair