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SMILES: Clc1nc(N2CCCC(C2)NC(=O)c2nccs2)c2ccc(cc2n1)N1CCOCC1

InChI Key: InChIKey=HSUSUBYASLVLBD-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 179357   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA-dependent protein kinase catalytic subunit


(Homo sapiens (Human))		BDBM179357
PNG
(US9126952, 60)
Show SMILES Clc1nc(N2CCCC(C2)NC(=O)c2nccs2)c2ccc(cc2n1)N1CCOCC1
Show InChI InChI=1S/C21H23ClN6O2S/c22-21-25-17-12-15(27-7-9-30-10-8-27)3-4-16(17)18(26-21)28-6-1-2-14(13-28)24-19(29)20-23-5-11-31-20/h3-5,11-12,14H,1-2,6-10,13H2,(H,24,29)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.425



Merck Patent GmbH

US Patent


Assay Description
The kinase assay was carried out in streptavidin-coated 348-well microtitre FlashPlates®. To this end, 1.5 μg of the DNA-PK/protein complex and ...

US Patent US9126952 (2015)


BindingDB Entry DOI: 10.7270/Q2JH3JZ2
More data for this
Ligand-Target Pair