BDBM181192 US9139529, 35::US9783501, Compound 35

SMILES: Fc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cc[nH]c(=O)c2)cc1

InChI Key: InChIKey=JMNSFSIFUWIACD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 181192   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 10 subunit alpha (Homo sapiens (Human))	BDBM181192 (US9139529, 35 | US9783501, Compound 35) Show SMILES Fc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cc[nH]c(=O)c2)cc1 Show InChI InChI=1S/C20H13FN4O3/c21-12-5-7-14(8-6-12)28-20-18(24-15-3-1-2-4-16(15)25-20)19(27)23-13-9-10-22-17(26)11-13/h1-11H,(H2,22,23,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9783501 (2017) BindingDB Entry DOI: 10.7270/Q25B04NS
					More data for this Ligand-Target Pair
Sodium channel protein type 10 subunit alpha (Rattus norvegicus (Rat))	BDBM181192 (US9139529, 35 | US9783501, Compound 35) Show SMILES Fc1ccc(Oc2nc3ccccc3nc2C(=O)Nc2cc[nH]c(=O)c2)cc1 Show InChI InChI=1S/C20H13FN4O3/c21-12-5-7-14(8-6-12)28-20-18(24-15-3-1-2-4-16(15)25-20)19(27)23-13-9-10-22-17(26)11-13/h1-11H,(H2,22,23,26,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
VERTEX PHARMACEUTICALS INCORPORATED US Patent					Assay Description Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...				US Patent US9139529 (2015) BindingDB Entry DOI: 10.7270/Q2ZG6R1Z
					More data for this Ligand-Target Pair