Found 4 hits for monomerid = 182518 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ribosomal protein S6 kinase beta-1
(Homo sapiens (Human)) | BDBM182518
(US9145392, 219)Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1ccc(F)cc1 Show InChI InChI=1S/C30H30F5N7/c31-22-5-2-19(3-6-22)26-27(36)37-18-38-29(26)41-12-8-20(9-13-41)28-39-25(17-42(28)15-14-40-10-1-11-40)21-4-7-24(32)23(16-21)30(33,34)35/h2-7,16-18,20H,1,8-15H2,(H2,36,37,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Patent GmbH
US Patent
| Assay Description
P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo... |
US Patent US9145392 (2015)
BindingDB Entry DOI: 10.7270/Q2NZ86D2 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM182518
(US9145392, 219)Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1ccc(F)cc1 Show InChI InChI=1S/C30H30F5N7/c31-22-5-2-19(3-6-22)26-27(36)37-18-38-29(26)41-12-8-20(9-13-41)28-39-25(17-42(28)15-14-40-10-1-11-40)21-4-7-24(32)23(16-21)30(33,34)35/h2-7,16-18,20H,1,8-15H2,(H2,36,37,38) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ERG by patch clamp assay |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128352
BindingDB Entry DOI: 10.7270/Q2SB49H5 |
More data for this
Ligand-Target Pair | |
RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM182518
(US9145392, 219)Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1ccc(F)cc1 Show InChI InChI=1S/C30H30F5N7/c31-22-5-2-19(3-6-22)26-27(36)37-18-38-29(26)41-12-8-20(9-13-41)28-39-25(17-42(28)15-14-40-10-1-11-40)21-4-7-24(32)23(16-21)30(33,34)35/h2-7,16-18,20H,1,8-15H2,(H2,36,37,38) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of Akt (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128352
BindingDB Entry DOI: 10.7270/Q2SB49H5 |
More data for this
Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM182518
(US9145392, 219)Show SMILES Nc1ncnc(N2CCC(CC2)c2nc(cn2CCN2CCC2)-c2ccc(F)c(c2)C(F)(F)F)c1-c1ccc(F)cc1 Show InChI InChI=1S/C30H30F5N7/c31-22-5-2-19(3-6-22)26-27(36)37-18-38-29(26)41-12-8-20(9-13-41)28-39-25(17-42(28)15-14-40-10-1-11-40)21-4-7-24(32)23(16-21)30(33,34)35/h2-7,16-18,20H,1,8-15H2,(H2,36,37,38) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Merck Patent GmbH
US Patent
| Assay Description
A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv... |
US Patent US9145392 (2015)
BindingDB Entry DOI: 10.7270/Q2NZ86D2 |
More data for this
Ligand-Target Pair | |
Search and Browse
