BDBM182615 US9145392, 316
SMILES: Cc1ccc(cc1C(F)(F)F)-c1cn(CCN2CCC2)c(n1)C1CCN(CC1)c1ncnc(N)c1C#N
InChI Key: InChIKey=NCEITWUOOXWJSM-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM182615 (US9145392, 316) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Merck Patent GmbH US Patent | Assay Description A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv... | US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human)) | BDBM182615 (US9145392, 316) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Merck Patent GmbH US Patent | Assay Description P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo... | US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2 | |||||||||||
More data for this Ligand-Target Pair |