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SMILES: CC(C)c1c(OC[C@@H](O)C[C@@H](O)CC(O)=O)n(nc1C(=O)N(C)Cc1cccc(F)c1)-c1ccc(F)cc1

InChI Key: InChIKey=BNRHLGGVKRLQEG-YADHBBJMSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18404   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-hydroxy-3-methylglutaryl-coenzyme A reductase


(Rattus norvegicus (rat))		BDBM18404
PNG
((3R,5S)-6-{[1-(4-fluorophenyl)-3-{[(3-fluorophenyl...)
Show SMILES CC(C)c1c(OC[C@@H](O)C[C@@H](O)CC(O)=O)n(nc1C(=O)N(C)Cc1cccc(F)c1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C27H31F2N3O6/c1-16(2)24-25(26(37)31(3)14-17-5-4-6-19(29)11-17)30-32(20-9-7-18(28)8-10-20)27(24)38-15-22(34)12-21(33)13-23(35)36/h4-11,16,21-22,33-34H,12-15H2,1-3H3,(H,35,36)/t21-,22+/m1/s1
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MMDB

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Similars
Article
PubMed
n/an/a 14n/an/an/an/a7.237



Pfizer



Assay Description
Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...

Bioorg Med Chem Lett 17: 5567-72 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.004
BindingDB Entry DOI: 10.7270/Q2ZS2TS7
More data for this
Ligand-Target Pair