BDBM18419 (3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-(1,2,3,4-tetrahydroisoquinolin-2-ylcarbonyl)-1H-pyrazol-5-yl]oxy}-3,5-dihydroxyhexanoic acid::oxypyrazole, 4ff

SMILES: CC(C)c1c(OC[C@@H](O)C[C@@H](O)CC(O)=O)n(nc1C(=O)N1CCc2ccccc2C1)-c1ccc(F)cc1

InChI Key: InChIKey=KKERRCWFTMXHDI-PKTZIBPZSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM18419 ((3R,5S)-6-{[1-(4-fluorophenyl)-4-(propan-2-yl)-3-(...) Show SMILES CC(C)c1c(OC[C@@H](O)C[C@@H](O)CC(O)=O)n(nc1C(=O)N1CCc2ccccc2C1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C28H32FN3O6/c1-17(2)25-26(27(37)31-12-11-18-5-3-4-6-19(18)15-31)30-32(21-9-7-20(29)8-10-21)28(25)38-16-23(34)13-22(33)14-24(35)36/h3-10,17,22-23,33-34H,11-16H2,1-2H3,(H,35,36)/t22-,23+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer					Assay Description Assay for HMG-CoA reductase was based on the conversion of isotopically labeled HMG-CoA to mevalonic acid using rat liver microsomes as enzyme source...				Bioorg Med Chem Lett 17: 5567-72 (2007) Article DOI: 10.1016/j.bmcl.2007.08.004 BindingDB Entry DOI: 10.7270/Q2ZS2TS7
					More data for this Ligand-Target Pair