null

SMILES: NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)n1c4ccc(cc4[nH]c1=O)C#N)C(C3)C2

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 186149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM186149 (US9163012, 66) Show SMILES NC(=O)[C@@]12CC3CC(C1)[C@H](OC(=O)N1CC[C@H](C1)n1c4ccc(cc4[nH]c1=O)C#N)C(C3)C2 |r,wU:9.10,16.19,wD:3.2,TLB:6:7:32:4.5.31,6:5:32:7.9.8,THB:9:7:4:32.30.31,9:30:4:7.6.8,10:9:32:4.5.31,(-9.33,-20.25,;-8,-21.02,;-8,-22.56,;-6.67,-20.25,;-7.5,-22.15,;-6.1,-21.51,;-4.9,-22.17,;-4,-20.25,;-5.33,-21.02,;-4,-18.71,;-2.67,-17.94,;-1.34,-18.71,;-1.34,-20.25,;-0,-17.94,;-0,-16.4,;1.46,-15.92,;2.37,-17.17,;1.46,-18.42,;3.91,-17.17,;4.81,-18.42,;4.49,-19.92,;5.64,-20.95,;7.1,-20.48,;7.42,-18.97,;6.28,-17.94,;6.28,-16.4,;4.81,-15.92,;4.04,-14.59,;8.24,-21.51,;9.33,-22.6,;-5.33,-17.94,;-6.09,-19.1,;-6.67,-18.71,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.48	n/a	n/a	n/a	n/a	n/a	25
Vitae Pharmaceuticals, Inc. US Patent					Assay Description Inhibition of microsomal preparations of 11.beta.-HSDl by compounds of the present invention, as described essentially previously (K. Solly, SS Mundt...				US Patent US9163012 (2015) BindingDB Entry DOI: 10.7270/Q2TD9W45
					More data for this Ligand-Target Pair