BDBM187285 US9169240, 25

SMILES: C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1

InChI Key: InChIKey=VSMPITHDNJHFPV-SNVBAGLBSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 187285   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM187285 (US9169240, 25) Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r| Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	86	n/a	n/a	n/a	n/a	8.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...				US Patent US9169240 (2015) BindingDB Entry DOI: 10.7270/Q2W66JK8
					More data for this Ligand-Target Pair
Hepatic Lipase (HL) (Homo sapiens (Human))	BDBM187285 (US9169240, 25) Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r| Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human HL expressed in human COS7 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addit...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM187285 (US9169240, 25) Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r| Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using A10070 as substrate preincubated for 20 min followed by DMPG vesicle doped substrate addition and measur...				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM187285 (US9169240, 25) Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r| Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by LC/MS analysis				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM187285 (US9169240, 25) Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r| Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of EL in human HT1080 cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysis				J Med Chem 63: 1660-1670 (2020) Article DOI: 10.1021/acs.jmedchem.9b01831
					More data for this Ligand-Target Pair