null

SMILES: Fc1cc(cc(F)c1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1)C1CC1

InChI Key: InChIKey=KRLFCFMEUJMYAZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188811   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM188811 (US9169260, 77) Show SMILES Fc1cc(cc(F)c1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CCNCC1)C1CC1 |(.43,3.1,;1.92,2.71,;3.01,3.79,;4.5,3.4,;4.89,1.91,;3.81,.82,;4.2,-.67,;2.32,1.22,;1.23,.13,;1.23,-1.41,;-.24,-1.89,;-1.14,-.64,;-.24,.61,;-.63,2.09,;-2.12,2.49,;-3.21,1.4,;-2.52,3.98,;-2.04,5.44,;-3.29,6.35,;-4.54,5.44,;-6.04,5.76,;-7.07,4.62,;-6.6,3.15,;-5.09,2.83,;-4.06,3.98,;-.63,-3.37,;-2.12,-3.77,;-2.52,-5.26,;-1.43,-6.35,;.06,-5.95,;.46,-4.46,;5.59,4.49,;7.07,4.88,;5.98,5.97,)| Show InChI InChI=1S/C24H23F2N7O/c25-18-10-16(14-2-3-14)11-19(26)22(18)33-21(12-20(31-33)15-4-7-27-8-5-15)30-24(34)17-13-29-32-9-1-6-28-23(17)32/h1,6,9-15,27H,2-5,7-8H2,(H,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.2	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...				US Patent US9169260 (2015) BindingDB Entry DOI: 10.7270/Q26H4G6N
					More data for this Ligand-Target Pair