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SMILES: Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CNC1)C1CC1

InChI Key: InChIKey=LIDCOYJXXSBVPZ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188821   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188821
PNG
(US9169260, 87)
Show SMILES Fc1cc(ccc1-n1nc(cc1NC(=O)c1cnn2cccnc12)C1CNC1)C1CC1
Show InChI InChI=1S/C22H20FN7O/c23-17-8-14(13-2-3-13)4-5-19(17)30-20(9-18(28-30)15-10-24-11-15)27-22(31)16-12-26-29-7-1-6-25-21(16)29/h1,4-9,12-13,15,24H,2-3,10-11H2,(H,27,31)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair