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SMILES: CC(C)N1CC(C1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1

InChI Key: InChIKey=CZPKVPBOYNZJBY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 188822   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))		BDBM188822
PNG
(US9169260, 88)
Show SMILES CC(C)N1CC(C1)c1cc(NC(=O)c2cnn3cccnc23)n(n1)-c1ccc(cc1F)C1CC1
Show InChI InChI=1S/C25H26FN7O/c1-15(2)31-13-18(14-31)21-11-23(29-25(34)19-12-28-32-9-3-8-27-24(19)32)33(30-21)22-7-6-17(10-20(22)26)16-4-5-16/h3,6-12,15-16,18H,4-5,13-14H2,1-2H3,(H,29,34)
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Similars
US Patent
n/an/a<100n/an/an/an/a7.2n/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK-4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phos...

US Patent US9169260 (2015)


BindingDB Entry DOI: 10.7270/Q26H4G6N
More data for this
Ligand-Target Pair