Found 5 hits for monomerid = 18952 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM18952
(2-[3,5-dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl...)Show SMILES COc1cccc(CCNC(=O)c2cc(Oc3c(Br)cc(CC(O)=O)cc3Br)ccc2O)c1 Show InChI InChI=1S/C24H21Br2NO6/c1-32-16-4-2-3-14(9-16)7-8-27-24(31)18-13-17(5-6-21(18)28)33-23-19(25)10-15(11-20(23)26)12-22(29)30/h2-6,9-11,13,28H,7-8,12H2,1H3,(H,27,31)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
| Assay Description IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. |
Bioorg Med Chem Lett 14: 3549-53 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.032 BindingDB Entry DOI: 10.7270/Q2736P5M |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM18952
(2-[3,5-dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl...)Show SMILES COc1cccc(CCNC(=O)c2cc(Oc3c(Br)cc(CC(O)=O)cc3Br)ccc2O)c1 Show InChI InChI=1S/C24H21Br2NO6/c1-32-16-4-2-3-14(9-16)7-8-27-24(31)18-13-17(5-6-21(18)28)33-23-19(25)10-15(11-20(23)26)12-22(29)30/h2-6,9-11,13,28H,7-8,12H2,1H3,(H,27,31)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
| Assay Description IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. |
Bioorg Med Chem Lett 14: 3549-53 (2004)
Article DOI: 10.1016/j.bmcl.2004.04.032 BindingDB Entry DOI: 10.7270/Q2736P5M |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor alpha
(Homo sapiens (Human)) | BDBM18952
(2-[3,5-dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl...)Show SMILES COc1cccc(CCNC(=O)c2cc(Oc3c(Br)cc(CC(O)=O)cc3Br)ccc2O)c1 Show InChI InChI=1S/C24H21Br2NO6/c1-32-16-4-2-3-14(9-16)7-8-27-24(31)18-13-17(5-6-21(18)28)33-23-19(25)10-15(11-20(23)26)12-22(29)30/h2-6,9-11,13,28H,7-8,12H2,1H3,(H,27,31)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 93.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de S£o Paulo
Curated by ChEMBL
| Assay Description Inhibition of thyroid hormone receptor alpha |
Bioorg Med Chem 15: 4609-17 (2007)
Article DOI: 10.1016/j.bmc.2007.04.015 BindingDB Entry DOI: 10.7270/Q2W37XJQ |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM18952
(2-[3,5-dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl...)Show SMILES COc1cccc(CCNC(=O)c2cc(Oc3c(Br)cc(CC(O)=O)cc3Br)ccc2O)c1 Show InChI InChI=1S/C24H21Br2NO6/c1-32-16-4-2-3-14(9-16)7-8-27-24(31)18-13-17(5-6-21(18)28)33-23-19(25)10-15(11-20(23)26)12-22(29)30/h2-6,9-11,13,28H,7-8,12H2,1H3,(H,27,31)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade de S£o Paulo
Curated by ChEMBL
| Assay Description Inhibition of thyroid hormone receptor beta |
Bioorg Med Chem 15: 4609-17 (2007)
Article DOI: 10.1016/j.bmc.2007.04.015 BindingDB Entry DOI: 10.7270/Q2W37XJQ |
More data for this Ligand-Target Pair | |
Thyroid hormone receptor beta
(Homo sapiens (Human)) | BDBM18952
(2-[3,5-dibromo-4-(4-hydroxy-3-{[2-(3-methoxyphenyl...)Show SMILES COc1cccc(CCNC(=O)c2cc(Oc3c(Br)cc(CC(O)=O)cc3Br)ccc2O)c1 Show InChI InChI=1S/C24H21Br2NO6/c1-32-16-4-2-3-14(9-16)7-8-27-24(31)18-13-17(5-6-21(18)28)33-23-19(25)10-15(11-20(23)26)12-22(29)30/h2-6,9-11,13,28H,7-8,12H2,1H3,(H,27,31)(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.51 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Insubria
Curated by ChEMBL
| Assay Description Inhibition of human thyroid hormone receptor beta 1 |
Bioorg Med Chem 15: 5251-61 (2007)
Article DOI: 10.1016/j.bmc.2007.05.016 BindingDB Entry DOI: 10.7270/Q2PK0HD8 |
More data for this Ligand-Target Pair | |