null

SMILES: CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCN(CC4)C4CCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1

InChI Key: InChIKey=JCBRSOXUSORGLN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 189578   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189578 (US10213433, Compound 140 | US11369599, Compound 14...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCN(CC4)C4CCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)18-14-34(42(29-48)32-6-8-35(49)9-7-32)31-54-22-24-56(25-23-54)38-10-12-41(45(27-38)63-39-26-33-15-19-50-46(33)51-30-39)47(58)53-64(61,62)40-11-13-43(44(28-40)57(59)60)52-36-16-20-55(21-17-36)37-4-3-5-37/h6-13,15,19,26-28,30,36-37,52H,3-5,14,16-18,20-25,29,31H2,1-2H3,(H,50,51)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
ABBVIE INC.; GENENTECH, INC.; THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH US Patent					Assay Description Representative compounds were serially diluted in dimethyl sulfoxide (DMSO) starting at 50 uM (2x starting concentration; 10% DMSO) and 10 uL were tr...				US Patent US9174982 (2015) BindingDB Entry DOI: 10.7270/Q2RB73D5
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189578 (US10213433, Compound 140 | US11369599, Compound 14...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCN(CC4)C4CCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)18-14-34(42(29-48)32-6-8-35(49)9-7-32)31-54-22-24-56(25-23-54)38-10-12-41(45(27-38)63-39-26-33-15-19-50-46(33)51-30-39)47(58)53-64(61,62)40-11-13-43(44(28-40)57(59)60)52-36-16-20-55(21-17-36)37-4-3-5-37/h6-13,15,19,26-28,30,36-37,52H,3-5,14,16-18,20-25,29,31H2,1-2H3,(H,50,51)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM189578 (US10213433, Compound 140 | US11369599, Compound 14...) Show SMILES CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NC4CCN(CC4)C4CCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:61| Show InChI InChI=1S/C48H55ClN8O6S/c1-48(2)18-14-34(42(29-48)32-6-8-35(49)9-7-32)31-54-22-24-56(25-23-54)38-10-12-41(45(27-38)63-39-26-33-15-19-50-46(33)51-30-39)47(58)53-64(61,62)40-11-13-43(44(28-40)57(59)60)52-36-16-20-55(21-17-36)37-4-3-5-37/h6-13,15,19,26-28,30,36-37,52H,3-5,14,16-18,20-25,29,31H2,1-2H3,(H,50,51)(H,53,58)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. US Patent					Assay Description TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay.				US Patent US10213433 (2019) BindingDB Entry DOI: 10.7270/Q23F4RZ6
					More data for this Ligand-Target Pair