BDBM192134 US9187437, 32
SMILES: Clc1cc(ccn1)-c1noc(CCC2(CCCCC2)c2ccccc2)n1
InChI Key: InChIKey=RDHDZYQPPWQRIT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM192134 (US9187437, 32) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | 7.5 | 25 |
BRISTOL-MYERS SQUIBB COMPANY US Patent | Assay Description Membranes were prepared from CHO cells expressing human S1P1. Cells pellets (1x108 cells/pellet) were suspended in buffer containing 20 mM HEPES, pH ... | US Patent US9187437 (2015) BindingDB Entry DOI: 10.7270/Q2JH3K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 3 (Homo sapiens (Human)) | BDBM192134 (US9187437, 32) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | 60 |
BRISTOL-MYERS SQUIBB COMPANY US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-G... | US Patent US9187437 (2015) BindingDB Entry DOI: 10.7270/Q2JH3K0X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sphingosine 1-phosphate receptor 1 (Homo sapiens (Human)) | BDBM192134 (US9187437, 32) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | 60 |
BRISTOL-MYERS SQUIBB COMPANY US Patent | Assay Description Compounds were loaded in a 384 Falcon v-bottom plate (0.5 ul/well in a 11 point, 3-fold dilution). Membranes prepared from S1P1/CHO cells or EDG3-G... | US Patent US9187437 (2015) BindingDB Entry DOI: 10.7270/Q2JH3K0X | |||||||||||
More data for this Ligand-Target Pair |