BDBM192546 US9187486, 8

SMILES: N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1

InChI Key: InChIKey=BOYINUVWSRXXKU-ZDUSSCGKSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 192546   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192546 (US9187486, 8) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9187486 (2015) BindingDB Entry DOI: 10.7270/Q24748NM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM192546 (US9187486, 8) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9187486 (2015) BindingDB Entry DOI: 10.7270/Q24748NM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM192546 (US9187486, 8) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1	UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	602	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM192546 (US9187486, 8) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM192546 (US9187486, 8) Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1nccs1 |r| Show InChI InChI=1S/C19H20N8S/c20-13-2-1-8-26(12-13)17-5-6-21-11-16(17)24-19-23-10-14-3-4-15(25-27(14)19)18-22-7-9-28-18/h3-7,9-11,13H,1-2,8,12,20H2,(H,23,24)/t13-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay				Bioorg Med Chem Lett 26: 5580-5590 (2016) Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M
					More data for this Ligand-Target Pair