Found 6 hits for monomerid = 192577 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)... |
US Patent US9187486 (2015)
BindingDB Entry DOI: 10.7270/Q24748NM |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)... |
US Patent US9187486 (2015)
BindingDB Entry DOI: 10.7270/Q24748NM |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase PIM
(Homo sapiens (Human)) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | PDB MMDB
UniProtKB/SwissProt UniProtKB/TrEMBL
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 286 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M |
More data for this Ligand-Target Pair | |
1,3-beta-glucan synthase component GLS2
(Saccharomyces cerevisiae) | BDBM192577
(US9187486, 40)Show SMILES N[C@H]1CCCN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C21H21FN8/c22-16-4-1-8-25-20(16)17-6-5-15-11-26-21(30(15)28-17)27-18-12-24-9-7-19(18)29-10-2-3-14(23)13-29/h1,4-9,11-12,14H,2-3,10,13,23H2,(H,26,27)/t14-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of radiolabeled dofetilide binding to human ERG expressed in HEK293 cells |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067 BindingDB Entry DOI: 10.7270/Q261128M |
More data for this Ligand-Target Pair | |