Found 5 hits for monomerid = 192645 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 15.3 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)... |
US Patent US9187486 (2015)
BindingDB Entry DOI: 10.7270/Q24748NM |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)... |
US Patent US9187486 (2015)
BindingDB Entry DOI: 10.7270/Q24748NM |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase PIM
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 258 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Pim1/2 in human KMS-12 cells assessed as decrease in BAD phosphorylation at Ser112 by Western blot method |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim1 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-2
(Homo sapiens (Human)) | BDBM192645
(US9187486, 96)Show SMILES C[C@@H]1CC[C@H](N)CN1c1ccncc1Nc1ncc2ccc(nn12)-c1ncccc1F |r| Show InChI InChI=1S/C22H23FN8/c1-14-4-5-15(24)13-30(14)20-8-10-25-12-19(20)28-22-27-11-16-6-7-18(29-31(16)22)21-17(23)3-2-9-26-21/h2-3,6-12,14-15H,4-5,13,24H2,1H3,(H,27,28)/t14-,15+/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant Pim2 (unknown origin) by electrochemiluminescence assay |
Bioorg Med Chem Lett 26: 5580-5590 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M |
More data for this
Ligand-Target Pair | |
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