BDBM192948 US9670204, 143 (S)-2-((2-ethyl-6-(1-(2-(3-hydroxypyrrolidin-1-yl)-2-oxoethyl)piperidin-4-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)[N+]#[C-])-c1ccc(F)cc1)C1CCN(CC(=O)N2CC[C@H](O)C2)CC1

InChI Key: InChIKey=KEWVYNVXZMUYFG-DEOSSOPVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 192948   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192948 (US9670204, 143 (S)-2-((2-ethyl-6-(1-(2-(3-hydroxyp...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)[N+]#[C-])-c1ccc(F)cc1)C1CCN(CC(=O)N2CC[C@H](O)C2)CC1 |r| Show InChI InChI=1S/C31H34FN7O2S/c1-4-25-30(36(3)31-35-28(29(33-2)42-31)21-5-8-23(32)9-6-21)39-17-22(7-10-26(39)34-25)20-11-14-37(15-12-20)19-27(41)38-16-13-24(40)18-38/h5-10,17,20,24,40H,4,11-16,18-19H2,1,3H3/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
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