BDBM192949 US10526329, Compound 144::US9670204, 144 2-((2-ethyl-6-(1-(2-(3-(hydroxymethyl)azetidin-1-yl)-2-oxoethyl)piperidin-4-yl)imidazo[1,2-a]pyridin-3-yl)(methyl)amino)-4-(4-fluorophenyl)thiazole-5-carbonitrile

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(CO)C2)CC1

InChI Key: InChIKey=OGXCDCKTMVUAEJ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192949   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192949 (US10526329, Compound 144 | US11072611, Compound 14...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(CO)C2)CC1 Show InChI InChI=1S/C31H34FN7O2S/c1-3-25-30(36(2)31-35-29(26(14-33)42-31)22-4-7-24(32)8-5-22)39-17-23(6-9-27(39)34-25)21-10-12-37(13-11-21)18-28(41)38-15-20(16-38)19-40/h4-9,17,20-21,40H,3,10-13,15-16,18-19H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192949 (US10526329, Compound 144 | US11072611, Compound 14...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(CO)C2)CC1 Show InChI InChI=1S/C31H34FN7O2S/c1-3-25-30(36(2)31-35-29(26(14-33)42-31)22-4-7-24(32)8-5-22)39-17-23(6-9-27(39)34-25)21-10-12-37(13-11-21)18-28(41)38-15-20(16-38)19-40/h4-9,17,20-21,40H,3,10-13,15-16,18-19H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192949 (US10526329, Compound 144 | US11072611, Compound 14...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C#N)-c1ccc(F)cc1)C1CCN(CC(=O)N2CC(CO)C2)CC1 Show InChI InChI=1S/C31H34FN7O2S/c1-3-25-30(36(2)31-35-29(26(14-33)42-31)22-4-7-24(32)8-5-22)39-17-23(6-9-27(39)34-25)21-10-12-37(13-11-21)18-28(41)38-15-20(16-38)19-40/h4-9,17,20-21,40H,3,10-13,15-16,18-19H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair