BDBM192978 US10526329, Compound 158::US9670204, 158 2-(4-(2-ethyl-3-((4-(4-fluorophenyl)-5-(2,2,2-trifluoroacetoyl)thiazol-2-yl)(methyl)amino)imidazo[1,2-a]pyridin-6-yl)piperazin-1-yl)-N,N-dimethylacetamide

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1

InChI Key: InChIKey=UMTXHWQAMFXILW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 192978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192978 (US10526329, Compound 158 | US11072611, Compound 15...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C29H31F4N7O2S/c1-5-21-27(37(4)28-35-24(18-6-8-19(30)9-7-18)25(43-28)26(42)29(31,32)33)40-16-20(10-11-22(40)34-21)39-14-12-38(13-15-39)17-23(41)36(2)3/h6-11,16H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192978 (US10526329, Compound 158 | US11072611, Compound 15...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C29H31F4N7O2S/c1-5-21-27(37(4)28-35-24(18-6-8-19(30)9-7-18)25(43-28)26(42)29(31,32)33)40-16-20(10-11-22(40)34-21)39-14-12-38(13-15-39)17-23(41)36(2)3/h6-11,16H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192978 (US10526329, Compound 158 | US11072611, Compound 15...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C29H31F4N7O2S/c1-5-21-27(37(4)28-35-24(18-6-8-19(30)9-7-18)25(43-28)26(42)29(31,32)33)40-16-20(10-11-22(40)34-21)39-14-12-38(13-15-39)17-23(41)36(2)3/h6-11,16H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192978 (US10526329, Compound 158 | US11072611, Compound 15...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C29H31F4N7O2S/c1-5-21-27(37(4)28-35-24(18-6-8-19(30)9-7-18)25(43-28)26(42)29(31,32)33)40-16-20(10-11-22(40)34-21)39-14-12-38(13-15-39)17-23(41)36(2)3/h6-11,16H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192978 (US10526329, Compound 158 | US11072611, Compound 15...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(c(s1)C(=O)C(F)(F)F)-c1ccc(F)cc1)N1CCN(CC(=O)N(C)C)CC1 Show InChI InChI=1S/C29H31F4N7O2S/c1-5-21-27(37(4)28-35-24(18-6-8-19(30)9-7-18)25(43-28)26(42)29(31,32)33)40-16-20(10-11-22(40)34-21)39-14-12-38(13-15-39)17-23(41)36(2)3/h6-11,16H,5,12-15,17H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent									US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair