BDBM192998 US10526329, Compound 178::US9670204, 178 2-(1-(2-ethyl-3-((4-(4-fluorophenyl)thiazol-2-yl)(methyl)amino)imidazo[1,2-a]pyridin-6-yl)azetidin-3-ylamino)-1-(3-hydroxyazetidin-1-yl)ethanone

SMILES: CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CC(C1)NCC(=O)N1CC(O)C1

InChI Key: InChIKey=OINJZCIRBASATK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 192998   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192998 (US10526329, Compound 178 | US11072611, Compound 17...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CC(C1)NCC(=O)N1CC(O)C1 Show InChI InChI=1S/C27H30FN7O2S/c1-3-22-26(32(2)27-31-23(16-38-27)17-4-6-18(28)7-5-17)35-13-20(8-9-24(35)30-22)33-11-19(12-33)29-10-25(37)34-14-21(36)15-34/h4-9,13,16,19,21,29,36H,3,10-12,14-15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	8.5	25
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate. 5 μL of a di...				US Patent US9670204 (2017) BindingDB Entry DOI: 10.7270/Q2W66HZS
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192998 (US10526329, Compound 178 | US11072611, Compound 17...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CC(C1)NCC(=O)N1CC(O)C1 Show InChI InChI=1S/C27H30FN7O2S/c1-3-22-26(32(2)27-31-23(16-38-27)17-4-6-18(28)7-5-17)35-13-20(8-9-24(35)30-22)33-11-19(12-33)29-10-25(37)34-14-21(36)15-34/h4-9,13,16,19,21,29,36H,3,10-12,14-15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (Homo sapiens (Human))	BDBM192998 (US10526329, Compound 178 | US11072611, Compound 17...) Show SMILES CCc1nc2ccc(cn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CC(C1)NCC(=O)N1CC(O)C1 Show InChI InChI=1S/C27H30FN7O2S/c1-3-22-26(32(2)27-31-23(16-38-27)17-4-6-18(28)7-5-17)35-13-20(8-9-24(35)30-22)33-11-19(12-33)29-10-25(37)34-14-21(36)15-34/h4-9,13,16,19,21,29,36H,3,10-12,14-15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description Compound IC50 values are determined in a hENPP2 (UniProtKB/SwissProt Sequence ref Q13822) biochemical assay using LPC as substrate.5 μL of a dil...				US Patent US10526329 (2020) BindingDB Entry DOI: 10.7270/Q2Z60RGR
					More data for this Ligand-Target Pair